|
Tumor M2-PK is a synonym for the dimeric form of the pyruvate kinase isoenzyme type M2 (PKM2), a key enzyme within tumor metabolism. Tumor M2-PK can be elevated in many tumor types, rather than being an organ-specific tumor marker such as PSA. Increased stool (fecal) levels are being investigated as a method of screening for colorectal tumors, and EDTA plasma levels are undergoing testing for possible application in the follow-up of various cancers. Sandwich ELISA’s based on two monoclonal antibodies which specifically recognize Tumor M2-PK (the dimeric form of M2-PK) are available for the quantification of Tumor M2-PK in stool and EDTA-plasma samples respectively. As a biomarker, the amount of Tumor M2-PK in stool and EDTA-plasma reflects the specific metabolic status of the tumors. == Early detection of colorectal tumors and polyps== M2-PK, as measured in feces, is a potential tumor marker for colorectal cancer. When measured in feces with a cutoff value of 4 U/ml, its sensitivity has been estimated to be 85% (with a 95% confidence interval of 65 to 96%) for colon cancer and 56% (confidence interval 41–74%) for rectal cancer. Its specificity is 95%.〔http://www.wjgnet.com/1007-9327/pdf/v18/i30/4004.pdf〕 The M2-PK test is not dependent on occult blood (ELISA method), so can detect bleeding or non-bleeding bowel cancer and also polyps with high sensivity and high specificity with no false negative, but false positive may be occur.〔(【引用サイトリンク】title=Tumor M2-PK Stool Test )〕 Most people are more willing to accept non-invasive preventive medical check-ups. Therefore, the measurement of Tumor M2-PK in stool samples, with follow-up by colonoscopy to clarify the Tumor M2-PK positive results, may prove to be an advance in the early detection of colorectal carcinomas. The CE marked M2-PK Test is available in form of an ELISA test for quantitative results or as point of care test to receive results within minutes. Tumor M2-PK is also useful to diagnose Lung cancer and better than SCC and NSE tumor markers. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Tumor M2-PK」の詳細全文を読む スポンサード リンク
|